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November 18, 2019
Gynecologic Cancers: Types, Symptoms and Screenings
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Gynecologic Cancers: Types, Symptoms and Screenings

Cancer can develop in several areas of the female reproductive tract, including the cervix, endometrium, fallopian tubes, ovaries, uterus and vagina. The symptoms and signs can vary depending on the type and location of the cancer, but the following are common signs to look for:

  • A lump or mass in the pelvic area or vagina
  • Difficult or painful urination
  • Gastrointestinal issues, such as gas, bloating or constipation
  • Itching
  • Pain during sexual intercourse, or vaginal bleeding after intercourse
  • Pain, swelling or a feeling of fullness or pressure in the abdomen or pelvis
  • Vaginal bleeding or discharge not related to menstrual periods
  • Menstruation that is heavy or irregular
  • Vaginal discharge that is clear, white, or tinged with blood

Cervical cancer

A slow developing form of cancer, cervical cancer is generally preceded by dysplasia abnormal cells appearing in the cervical tissue. Specific types of human papillomavirus (HPV) that are transmitted through sexual contact are the cause of almost all cervical cancers. The main types of cervical cancer are squamous cell carcinoma (developing in the thin, flat cells lining the cervix) and adenocarcinoma (developing in the cervical cells that make mucus and other fluids).

Uterine cancer

Uterine cancer that develops in the endometrium the inner lining of the uterus is also called endometrial cancer. Most uterine cancers are adenocarcinomas (cancers that begin in cells that make mucus and other fluids). Uterine sarcoma, an uncommon form of uterine cancer, forms in the muscle and tissue that support the uterus and is often very aggressive.

Ovarian, fallopian tube and primary peritoneal cancer

Ovarian, fallopian tube and primary peritoneal cancers combined are the fifth-leading cause of cancer death in women in the U.S. Because they may not cause symptoms or exhibit early warning signs and because there is no screening test, they are often found at advanced stages. Risk factors for ovarian, fallopian tube and primary peritoneal cancers include having a family history of ovarian cancer or hereditary nonpolyposis colorectal cancer (HNPCC; Lynch syndrome), and having an inherited gene mutations such as BRCA1 and BRCA2. Genetic tests that detect mutated genes may be conducted for family members with a high risk of cancer.

Vaginal cancer

Vaginal cancer includes squamous cell carcinoma (the most common type), adenocarcinoma, melanoma and sarcoma. Vaginal cancer can be found during a routine pelvic exam and can be treated effectively when detected early. Certain factors can increase the risk of developing vaginal cancer including:

  • Being age 60 or older
  • Being exposed to DES (administered to women in the 1950s to prevent miscarriages)
  • Having human papilloma virus (HPV) infection
  • Having a history of abnormal cells in the cervix or cervical cancer
  • Having a history of abnormal cells in the uterus or cancer of the uterus
  • Having had a hysterectomy for health problems that affect the uterus

Vulvar cancer

Vulvar cancer includes squamous cell carcinoma (the most common) and adenocarcinoma, with half of all vulvar cancers caused by infection with certain types of human papillomavirus (HPV). Vulvar cancer develops slowly and can be preceded by the growth of abnormal cells (vulvar intraepithelial neoplasia or VIN) on the surface of the vulvar skin. Signs of vulvar cancer typically include a lump, bleeding, or itching.

Screening tests for gynecologic cancers

Talk with your doctor about the frequency at which you need HPT testing and PAP testing based on your age, personal history and risk factors.


National Cancer Institute (NCI)

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